M-Sol vs Myofolic: Best Myofolic Alternative Pakistan 2026

Shop the picks in this guide (4)

• M-Sol Myo-Inositol Sachet, Rs 950, the local myo-inositol sachet with melatonin and folic acid for women trying to conceive
• Simfolic Myo-Inositol + Folic Acid, Rs 1,390, the closest match to Myofolic's 2000 mg myo-inositol with 400 mcg folic acid
• Nutrifactor Ovacep 40:1 Inositol Sachets, Rs 4,000, for the researched 40:1 myo to D-chiro ratio, 30 sachets
• Nutrifactor Oxitol Inositol Capsules, Rs 1,150, a lower-dose myo and D-chiro inositol capsule if sachets are awkward when travelling

What is Myofolic sachet?

Myofolic is a myo-inositol sachet made by Matrix Pharmaceuticals (Pvt) Ltd, prescribed widely in Pakistan for PCOS, irregular cycles and fertility support. Each sachet dissolves in water and is normally taken once a day, usually for at least three months, because inositol works on cycle regularity slowly rather than overnight.

Myofolic composition (per sachet)

• Myo-inositol: 2000 mg
• Folic acid: 400 mcg

That is the composition Pakistani pharmacies list for Myofolic (checked in September 2026). It does not contain D-chiro inositol, so it is a plain myo-inositol and folic acid product rather than a 40:1 blend. If you have read elsewhere that Myofolic is a 40:1 product, check the pack: the 40:1 sachets on the Pakistani market are different brands.

Myofolic price in Pakistan

Myofolic sells for roughly Rs 1,200 to Rs 1,490 for a box of 15 sachets, depending on the pharmacy (prices checked at major Pakistani pharmacy chains and online pharmacies in September 2026). PCOS support runs for months, so the monthly cost is what most women end up weighing. We do not stock Myofolic. We stock M-Sol at Rs 950, and the rest of this guide compares the two honestly so you can decide which suits you.

What is M-Sol Sachet?

M-Sol is a fertility supplement from NB Sons, a Pakistani supplement brand. It is formulated for women who are trying to conceive and for women who want steadier cycles, including women with PCOS. It is built around the same 2000 mg myo-inositol dose used in most published PCOS research, and adds melatonin as an antioxidant for egg cells.

M-Sol Composition (Per Sachet):

1. Myo-Inositol: 2000 mg
2. Melatonin: 1 mg
3. Folic Acid (Vitamin B9): 200 mcg

How M-Sol Works:

1. Supports Insulin Sensitivity
Myo-inositol is a second messenger in the insulin signalling pathway. In women with PCOS, who often have insulin resistance, supplementing it helps cells respond to insulin. A 2018 study in the Journal of Ovarian Research found the HOMA index (a marker of insulin resistance) fell from 5.5 to 3.3 in women who responded to 2 g of myo-inositol twice a day for three months. Note that the study dose was two 2 g doses a day, while M-Sol and Myofolic are usually taken as one sachet a day, so ask your gynaecologist what dose suits you.

2. Supports Ovulation
In that same study, 23 of 37 women with PCOS and anovulation (62%) ovulated after three months of myo-inositol, while the rest did not respond. That is a helpful, honest picture: it works for many women, not for all.

3. Supports Egg Quality
Myo-inositol is used before natural conception and before IVF or IUI for follicle and egg development. M-Sol's melatonin is there as an antioxidant to help protect egg cells, according to NB Sons' own product description.

4. May Ease PCOS Symptoms
High androgens drive many PCOS symptoms. In the 2018 study above, testosterone fell and SHBG rose in the women given myo-inositol together with alpha-lactalbumin, and the myo-inositol responders were not measured for those two hormones, so treat this as supporting evidence rather than a result for myo-inositol on its own. The symptoms androgens drive include:

1. Irregular or absent periods
2. Excess facial or body hair (hirsutism)
3. Acne and oily skin
4. Weight gain and trouble losing weight
5. Raised testosterone levels

Who Should Use M-Sol?

1. Women diagnosed with PCOS
2. Those with irregular menstrual cycles
3. Couples trying to conceive
4. Women preparing for IVF or IUI treatment
5. Anyone with insulin resistance linked to PCOS

What is Myofolic?

Myofolic is a widely prescribed myo-inositol sachet from Matrix Pharmaceuticals (Pvt) Ltd, a Pakistani company. Gynaecologists across Pakistan prescribe it for PCOS, and many women trying to conceive know it by name.

Myofolic Composition (Per Sachet):

1. Myo-Inositol: 2000 mg
2. Folic Acid: 400 mcg

How Myofolic Works:

The way it works is the same as M-Sol, because the main active is the same 2000 mg of myo-inositol. Myofolic works by:

1. Improving Insulin Sensitivity
Inositol acts as a second messenger for insulin. It helps cells respond better to insulin signals. This is vital for PCOS patients, who often have insulin resistance.

2. Regulating Menstrual Cycles
By supporting insulin and hormone balance, myo-inositol helps many women get more regular cycles. Give it at least three months before you judge it.

3. Reducing Androgen Levels
High androgen (male hormone) levels are a hallmark of PCOS. In women who respond to myo-inositol, testosterone often falls. That eases symptoms like excess hair growth and acne.

4. Supporting Fertility
Clinical studies show that myo-inositol improves ovulation rates in women with PCOS, although a 2024 meta-analysis of 30 trials found the overall evidence "limited and inconclusive", with no clear difference in pregnancy rates for myo-inositol plus folic acid against folic acid alone. Read that as "helpful for cycles and ovulation, not a guarantee of pregnancy".

Who Should Use Myofolic?

The target group is the same as M-Sol:

1. Women with diagnosed PCOS
2. Those struggling with infertility
3. Women with insulin resistance
4. Patients undergoing fertility treatments

Side-by-Side Ingredient Comparison

Active Ingredients

M-Sol and Myofolic share the same core active at the same dose, and differ on the extras:

Myo-Inositol: 2000 mg (both)

1. The primary active ingredient
2. The most studied inositol for PCOS
3. Supports insulin sensitivity
4. Supports egg quality and ovulation
5. May lower testosterone in women who respond

Folic Acid: 200 mcg in M-Sol, 400 mcg in Myofolic

1. Essential for cell division and DNA synthesis
2. Helps protect against neural tube defects if pregnancy occurs
3. Recommended for all women of childbearing age
4. If you want the full 400 mcg preconception dose, Myofolic has it, and so does our Simfolic (2000 mg myo-inositol with 400 mcg folic acid)

Melatonin: 1 mg in M-Sol, none in Myofolic

1. Included as an antioxidant for egg cells
2. Taken at night it may make you drowsy, which is why some women take M-Sol in the evening

D-Chiro Inositol: none in either

1. Neither M-Sol nor Myofolic is a 40:1 product
2. A 2019 trial that compared seven myo to D-chiro ratios found 40:1 the best for restoring ovulation, and that pushing the ratio towards more D-chiro made results worse
3. If your doctor wants 40:1, look at Nutrifactor Ovacep (2000 mg myo-inositol with 50 mg D-chiro per sachet). Nutrifactor Oxitol capsules also pair myo-inositol with D-chiro inositol, but at a lower dose and not at 40:1 (400 mg myo-inositol with 25 mg D-chiro per capsule), so treat them as a different option rather than a 40:1 substitute

Quality & Standards

M-Sol:

1. From NB Sons, a Pakistani supplement brand
2. Sold as a dietary supplement, not a drug
3. Full composition printed on the pack and on our product page

Myofolic:

1. From Matrix Pharmaceuticals (Pvt) Ltd, a Pakistani company
2. Sold over the counter, no prescription needed
3. Stocked by the large pharmacy chains and online pharmacies

Formulation Differences

The format is the same. Both products are:

1. Powder sachets
2. Dissolved in water
3. Taken once daily
4. Built around 2000 mg of myo-inositol

The formulation differences are the ones above: M-Sol adds melatonin and carries half the folic acid.

Price Comparison: M-Sol vs Myofolic in Pakistan

This is where M-Sol has a clear advantage on the pack price. M-Sol is Rs 950 on yellowpink.pk. Myofolic was Rs 1,200 to Rs 1,490 for 15 sachets at major Pakistani pharmacies when we checked in September 2026. Compare the sachet count on each pack before you work out your monthly cost.

Why the Price Difference?

In our view, M-Sol is cheaper because:

1. Direct Distribution: Sold direct through yellowpink.pk with fewer middlemen
2. Lower Marketing Costs: Less brand and doctor-detailing spend built into the price
3. Local Pricing: Priced for long-term use in Pakistan

Myofolic costs more, we think, because:

1. Brand Premium: An established, doctor-prescribed brand charges more
2. Pharmacy Margins: Chain pharmacy pricing varies, and the discounts come and go
3. More Folic Acid: 400 mcg against 200 mcg, a small real difference in what you get

Value for Money

Both products deliver 2000 mg of myo-inositol per sachet, which is the part that does the work for PCOS. So on pack price M-Sol offers better value on the main active, as long as the sachet count on the pack works for you. PCOS management needs long-term use, usually 6 to 12 months, which makes affordability a key factor.

Money saved on the sachets is money you can put toward:

1. Fertility support for both partners (Repro-M for him, Repro-F for her)
2. Healthy diet and lifestyle changes
3. Medical consultations
4. Prenatal vitamins when pregnancy occurs

Effectiveness: Which Works Better?

The honest answer is that on the main active they should work the same.

M-Sol and Myofolic use the same 2000 mg myo-inositol dose. How well either works depends on:

1. Individual Response

Every woman's body responds differently. Factors include:

1. Severity of PCOS
2. BMI and weight
3. Level of insulin resistance
4. Age
5. Overall health
6. Diet and lifestyle

2. Consistency of Use

Results usually appear after:

1. 2 to 3 months: Better menstrual regularity
2. 3 to 6 months: Hormonal balance, fewer symptoms
3. 6 to 12 months: Best fertility outcomes

You must take it daily for at least 3 months to see real results. The studies that measured ovulation ran for three months before judging response.

3. Lifestyle Factors

Inositol supplements work best alongside:

1. A balanced diet (low glycaemic index foods)
2. Regular exercise (30 minutes a day)
3. Stress management
4. Enough sleep
5. Avoiding processed foods and sugars

Clinical Evidence

Here is what the research we can point you to actually found:

1. Ovulation: 62% of women with PCOS and anovulation (23 of 37) ovulated after three months of 2 g myo-inositol twice a day (double the usual once-daily sachet), in a 2018 study
2. Insulin sensitivity: In the same study, the HOMA index fell from 5.5 to 3.3 in responders
3. Androgens: In the same study, testosterone fell and SHBG rose in the women given myo-inositol with alpha-lactalbumin. The myo-inositol-only responders were not measured for those hormones, so read this as supporting evidence rather than a myo-inositol result
4. The 40:1 ratio: A 2019 trial of 56 women found the 40:1 myo to D-chiro ratio the best of seven ratios for restoring ovulation. Neither M-Sol nor Myofolic contains D-chiro inositol; Ovacep does
5. The big picture: A 2024 systematic review of 30 trials concluded that the evidence for inositol in PCOS is "limited and inconclusive", with fewer stomach side effects than metformin

These findings apply to both M-Sol and Myofolic, since they share the same myo-inositol dose. Talk to your gynaecologist about where inositol fits in your own plan.

Availability in Pakistan

M-Sol Availability

Where to Buy M-Sol:

1. Yellow Pink: yellowpink.pk, with cash on delivery across Pakistan
2. Cities: We deliver to Karachi, Lahore, Islamabad, Rawalpindi, Multan, Faisalabad, Peshawar, Quetta and the rest of the country

Myofolic Availability

Where to Buy Myofolic:

1. Pharmacy chains: The large chains in major cities list it
2. Online pharmacies: Several Pakistani online pharmacies list it, at prices that vary by seller
3. Yellow Pink: We do not stock it

Which Should You Choose?

Choose M-Sol if:

You want the lower pack price for long-term use
You like the idea of melatonin as extra antioxidant support for egg cells
You want cash on delivery to your door anywhere in Pakistan
You want the same 2000 mg myo-inositol dose at a lower cost
You are on a budget but still want a properly dosed product

Choose Myofolic if:

Your doctor specifically recommends this brand
You want the full 400 mcg of folic acid in the same sachet (or pick Simfolic, which has it too)
You would rather avoid melatonin
You have already started with Myofolic and want to stay consistent
It is easily available at your local pharmacy

The Practical Recommendation

For most Pakistani women with PCOS who are paying for inositol month after month, M-Sol is the sensible choice. Here is why:

1. Same myo-inositol dose, lower pack price
2. Easy to reorder with cash on delivery
3. Long-term affordability (crucial for PCOS management)
4. Melatonin added for egg-cell antioxidant support

Already using Myofolic and seeing results? You can switch to M-Sol without changing your myo-inositol dose. The only things that change are the folic acid (200 mcg instead of 400 mcg) and the added melatonin, so mention the switch to your gynaecologist.

How to Use M-Sol or Myofolic

Dosage

Standard Dosage: 1 sachet daily, or as directed by your gynaecologist

When to Take

1. Same time every day: Consistency matters more than the hour
2. M-Sol and melatonin: Because M-Sol contains 1 mg of melatonin, some women prefer it in the evening

How to Take

1. Empty one sachet into a glass of water (150 to 200 ml)
2. Stir until fully dissolved
3. Drink right away
4. Take it with or without food

Duration of Treatment

1. Minimum: 3 months for first results
2. Optimal: 6 to 12 months for full hormonal balance
3. Maintenance: Some women continue long-term, as advised by their doctor

Safety & Side Effects

M-Sol and Myofolic are both generally well tolerated. Cleveland Clinic notes that healthcare providers generally consider inositol safe when taken in low doses for up to 10 weeks, and lists diarrhoea, nausea, abdominal pain, fatigue, headache and dizziness as the side effects to watch for.

Common (But Rare) Side Effects:

1. Mild nausea
2. Bloating or gas
3. Mild stomach discomfort or abdominal pain
4. Diarrhoea
5. Fatigue, headache or dizziness
6. Drowsiness from the melatonin in M-Sol

How to Minimise Side Effects:

1. Take it with food
2. Start with half a sachet for the first few days
3. Drink plenty of water
4. Build up to the full dose gradually

Who Should NOT Use:

Talk to your doctor before use if you:

1. Are pregnant (your doctor may prefer a prenatal with folic acid on its own)
2. Have diabetes and take medication (inositol affects blood sugar, so do not change prescribed medicines without talking to your doctor)
3. Have kidney disease
4. Are allergic to any ingredients
5. Are under 18 years old

Drug Interactions

Interactions are minimal. Still, tell your doctor if you take:

1. Diabetes medications (the dose may need adjusting)
2. Sleep medicines or sedatives (M-Sol's melatonin adds to them)
3. Blood thinners

User Reviews: M-Sol vs Myofolic

We do not publish reviews we cannot verify. Two things worth keeping in mind when you read any inositol review: the studies above needed three months before they could tell responders from non-responders, so a review written at week two says little, and a review that mentions price is talking about the pack, so check the sachet count.

M-Sol User Feedback (Pakistan)

Reviews from M-Sol buyers appear on the product page as they come in, and we leave them as written. If sachets are awkward when you travel, Oxitol capsules are the easy fix.

Myofolic User Feedback (Pakistan)

We do not sell Myofolic, so we cannot vouch for reviews of it either way. Pharmacy sites carry buyer reviews; read them with the same two checks, how long the reviewer had been taking it and which pack size the price refers to.

Conclusion: M-Sol is the Best Myofolic Alternative in Pakistan

Compare every angle, ingredients, price, availability and evidence, and M-Sol comes out ahead for most Pakistani women who need to stay on inositol for months.

Here is why:

Same 2000 mg myo-inositol dose, lower pack price
A Pakistani brand, NB Sons
Delivered anywhere in Pakistan on cash on delivery
Melatonin added as antioxidant support for egg cells
Honest about what it is: a myo-inositol sachet, not a 40:1 blend

Myofolic is a good product. But there is no reason to pay more for the same myo-inositol dose when M-Sol gives you it for less. If your gynaecologist wants the 40:1 ratio, that is a different product, and Ovacep is the one to look at.

If you are serious about managing PCOS long-term, affordability and availability matter just as much as the dose. M-Sol delivers on all three.

Ready to Start Your PCOS Treatment Journey?

Order M-Sol today and get the same 2000 mg myo-inositol dose as Myofolic at a lower pack price.

Visit: yellowpink.pk/product/m-sol-sachet
Delivery: Cash on delivery across Pakistan

Take control of your hormonal health. Your journey to steadier cycles and better fertility starts with one sachet a day.

Disclaimer: This article is for information only and does not replace medical advice. Always consult a qualified gynaecologist or healthcare provider before starting any supplement, especially if you have underlying health conditions or take other medications. M-Sol is a dietary supplement; not intended to diagnose, treat, cure or prevent any disease.

This article was written and medically reviewed to our medical review board standards and is for general guidance, not personal medical advice. Always speak to a doctor or pharmacist about your own situation.

Ready to start? Order M-Sol Sachet at Rs 950, or browse the rest of our women's health range for Simfolic, Ovacep and the folate options mentioned above. Cash on delivery across Pakistan, and free delivery on orders over Rs 5,000 in Punjab.

Shop M-Sol Sachet →